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1

Five-stranded β-sheet sandwiched with two α-helices: A structural link between restriction endonucleases EcoRI and EcoRV

Česlovas Venclovas, Albertas Timinskas, Virginijus Siksnys

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1994

Language:

english

File:

PDF, 386 KB

english, 1994

2

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

Sapranauskas, R., Gasiunas, G., Fremaux, C., Barrangou, R., Horvath, P., Siksnys, V.

Journal:

Nucleic Acids Research

Year:

2011

Language:

english

File:

PDF, 1.73 MB

english, 2011

3

[ACM Press the 28th International Conference - Budapest, Hungary (2016.07.18-2016.07.20)] Proceedings of the 28th International Conference on Scientific and Statistical Database Management - SSDBM '16 - SolveDB

Šikšnys, Laurynas, Pedersen, Torben Bach

Year:

2016

Language:

english

File:

PDF, 638 KB

english, 2016

4

Methods for decoding Cas9 protospacer adjacent motif (PAM) sequences: A brief overview

Karvelis, Tautvydas, Gasiunas, Giedrius, Siksnys, Virginijus

Journal:

Year:

2017

Language:

english

File:

PDF, 580 KB

english, 2017

5

The dynamics of the monomeric restriction endonuclease BcnI during its interaction with DNA

Kostiuk, Georgij, Dikić, Jasmina, Schwarz, Friedrich W., Sasnauskas, Giedrius, Seidel, Ralf, Siksnys, Virginijus

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 2.80 MB

english, 2017

6

The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor

Toliusis, Paulius, Tamulaitiene, Giedre, Grigaitis, Rokas, Tuminauskaite, Donata, Silanskas, Arunas, Manakova, Elena, Venclovas, Česlovas, Szczelkun, Mark D, Siksnys, Virginijus, Zaremba, Mindaugas

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 6.67 MB

english, 2018

7

From Restriction Enzymes to CRISPR: An Interview with Virginijus Siksnys

Davies, Kevin, Siksnys, Virginijus

Journal:

The CRISPR Journal

Year:

2018

Language:

english

File:

PDF, 288 KB

english, 2018

8

Operational stability of copolymerized enzymes at elevated temperatures

V. V. Mozhaev, V. A. Šikšnis, V. P. Torchilin, Karel Martinek

Journal:

Biotechnology and Bioengineering

Year:

1983

Language:

english

File:

PDF, 465 KB

english, 1983

9

High stability to irreversible inactivation at elevated temperatures of enzymes covalently modified by hydrophilic reagents: α-Chymotrypsin

Vadim V. Mozhaev, Nickolay S. Melik-Nubarov, Vladislav Y. U. Levitsky, Virginius A. Siksnis, Karel Martinek

Journal:

Biotechnology and Bioengineering

Year:

1992

Language:

english

File:

PDF, 1.14 MB

english, 1992

10

Use of Specific Oligonucleotide Duplexes to Stimulate Cleavage of Refractory DNA Sites by Restriction Endonucleases

M. Reuter, D. Kupper, C.D. Pein, M. Petrusyte, V. Siksnys, B. Frey, D.H. Kruger

Journal:

Analytical Biochemistry

Year:

1993

File:

PDF, 470 KB

1993

11

Protein stabilization via hydrophilization: Stabilization of α-chymotrypsin by reductive alkylation with glyoxylic acid

N. S. Melik-Nubarov, V. V. Mozhaev, S. Šikšnis, Karel Martinek

Journal:

Biotechnology Letters

Year:

1987

Language:

english

File:

PDF, 285 KB

english, 1987

12

Restriction endonucleases that resemble a component of the bacterial DNA repair machinery

M. Sokolowska, M. Kaus-Drobek, H. Czapinska, G. Tamulaitis, V. Siksnys, M. Bochtler

Journal:

Cellular and Molecular Life Sciences

Year:

2007

Language:

english

File:

PDF, 645 KB

english, 2007

13

10.1038/79032

Deibert, Markus, Siksnys, Virginijus, Grazulis, Saulius, Sasnauskas, Giedrius, Huber, Robert

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 875 KB

english, 2000

14

Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system

Sinkunas, Tomas, Gasiunas, Giedrius, Fremaux, Christophe, Barrangou, Rodolphe, Horvath, Philippe, Siksnys, Virginijus

Journal:

The EMBO Journal

Year:

2011

Language:

english

File:

PDF, 961 KB

english, 2011

15

Different enzymes with similar structures involved in Mg2+-mediated polynucleotidyl transfer

Venclovas, Česlovas, Siksnys, Virginijus

Journal:

Natural Structural Biology

Year:

1995

File:

PDF, 472 KB

1995

16

Nucleotide flips determine the specificity of the Ecl18kI restriction endonuclease

Bochtler, Matthias, Szczepanowski, Roman H, Tamulaitis, Gintautas, Grazulis, Saulius, Czapinska, Honorata, Manakova, Elena, Siksnys, Virginijus

Journal:

The EMBO Journal

Year:

2006

Language:

english

File:

PDF, 515 KB

english, 2006

17

Role of the reactive cysteine residue in restriction endonuclease Cfr9I

Virginius Siksnys, Milda Pleckaityte

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1992

Language:

english

File:

PDF, 634 KB

english, 1992

18

The Crystal Structure of the Rare-Cutting Restriction Enzyme SdaI Reveals Unexpected Domain Architecture

Giedre Tamulaitiene, Arturas Jakubauskas, Claus Urbanke, Robert Huber, Saulius Grazulis, Virginijus Siksnys

Journal:

Year:

2006

Language:

english

File:

PDF, 664 KB

english, 2006

19

NotI Is Not Boring

Giedre Tamulaitiene, Virginijus Siksnys

Journal:

Year:

2008

Language:

english

File:

PDF, 188 KB

english, 2008

20

Protein stabilization via hydrophilization : Covalent modification of trypsin and α-chymotrypsin

Vadim V. MOZHAEV, Virginius A. ŠIKŠNIS, Nikolay S. MELIK-NUBAROV, Nida Z. GALKANTAITE, Gervydas J. DENIS, Eugenius P. BUTKUS, Boris Yu. ZASLAVSKY, Nataliya M. MESTECHKINA, Karel MARTINEK

Journal:

Year:

1988

Language:

english

File:

PDF, 799 KB

english, 1988

21

Catalytic and binding properties of restriction endonuclease Cfr9I

Virginius SIKSNYS, Milda PLECKAITYTE

Journal:

Year:

1993

Language:

english

File:

PDF, 1.09 MB

english, 1993

22

Electrostatic effects in trypsin reactions : Influence of salts

Vello TÕUGU, Toomas TIIVEL, Peeter TALTS, Virginius ŠIKŠNIS, Svetlana POYARKOVA, Tõnu KESVATERA, Aavo AAVIKSAAR

Journal:

Year:

1994

Language:

english

File:

PDF, 697 KB

english, 1994

23

Reversible conformational transition gives rise to ‘zig-zag’ temperature dependence of the rate constant of irreversible thermoinactivation of enzymes

Vladislav Yu. LEVITSKY, Nikolay S. MELIK-NUBAROV, Virginius A. SIKSNIS, Valeriy Ya. GRINBERG, Tatyana V. BUROVA, Andrey V. LEVASHOV, Vadim V. MOZHAEV

Journal:

Year:

1994

Language:

english

File:

PDF, 1.31 MB

english, 1994

24

Conversion of the Tetrameric Restriction Endonuclease Bse634I into a Dimer: Oligomeric Structure–Stability–Function Correlations

M. Zaremba, G. Sasnauskas, C. Urbanke, V. Siksnys

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 932 KB

english, 2005

25

Monomeric Restriction Endonuclease BcnI in the Apo Form and in an Asymmetric Complex with Target DNA

Monika Sokolowska, Magdalena Kaus-Drobek, Honorata Czapinska, Gintautas Tamulaitis, Roman H. Szczepanowski, Claus Urbanke, Virginijus Siksnys, Matthias Bochtler

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 928 KB

english, 2007

26

Crystal Structure ofCitrobacter freundiiRestriction EndonucleaseCfr10I at 2.15 Å Resolution

Damir Bozic, Saulius Grazulis, Virginijus Siksnys, Robert Huber

Journal:

Journal of Molecular Biology

Year:

1996

Language:

english

File:

PDF, 4.47 MB

english, 1996

27

Structure-based redesign of the Catalytic/Metal binding site of Cfr 10I restriction endonuclease reveals importance of spatial rather than sequence conservation of active centre residues

Remigijus Skirgaila, Saulius Grazulis, Damir Bozic, Robert Huber, Virginijus Siksnys

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 566 KB

english, 1998

28

The Cfr10I restriction enzyme is functional as a tetramer

Virginijus Siksnys, Remigijus Skirgaila, Giedrius Sasnauskas, Claus Urbanke, Dmitry Cherny, Saulius Grazulis, Robert Huber

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 641 KB

english, 1999

29

DNA cleavage reactions by type II restriction enzymes that require two copies of their recognition sites

Michelle L. Embleton, Virginijus Siksnys, Stephen E. Halford

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 282 KB

english, 2001

30

Sequence similarity among type-II restriction endonucleases, related by their recognized 6-bp target and tetranucleotide-overhang cleavage

Virginijus Siksnys, Albertas Timinskas, Saulius Klimašauskas, Viktoras Butkus, Arvydas Janulaitis

Journal:

Year:

1995

Language:

english

File:

PDF, 404 KB

english, 1995

31

Evidence for substrate-assisted catalysis in the DNA cleavage of several restriction endonucleases

Albert Jeltsch, Milda Pleckaityte, Ursel Selent, Heiner Wolfes, Virginius Siksnys, Alfred Pingoud

Journal:

Year:

1995

Language:

english

File:

PDF, 544 KB

english, 1995

32

Biochemical and mutational analysis of EcoRII functional domains reveals evolutionary links between restriction enzymes

Gintautas Tamulaitis, Merlind Mucke, Virginijus Siksnys

Journal:

Year:

2006

Language:

english

File:

PDF, 367 KB

english, 2006

33

Generation of the BfiI Restriction Endonuclease from the Fusion of a DNA Recognition Domain to a Non-specific Nuclease from the Phospholipase D Superfamily

Mindaugas Zaremba, Claus Urbanke, Stephen E. Halford, Virginijus Siksnys

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 890 KB

english, 2004

34

Simultaneous Binding of Three Recognition Sites is Necessary for a Concerted Plasmid DNA Cleavage by EcoRII Restriction Endonuclease

Gintautas Tamulaitis, Giedrius Sasnauskas, Merlind Mucke, Virginijus Siksnys

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 760 KB

english, 2006

35

Allosteric Communication Network in the Tetrameric Restriction Endonuclease Bse634I

Mindaugas Zaremba, Giedrius Sasnauskas, Claus Urbanke, Virginijus Siksnys

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.56 MB

english, 2006

36

The Recognition Domain of the BpuJI Restriction Endonuclease in Complex with Cognate DNA at 1.3-Å Resolution

Rasa Sukackaite, Saulius Grazulis, Matthias Bochtler, Virginijus Siksnys

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.92 MB

english, 2008

37

Oligomeric Structure Diversity within the GIY-YIG Nuclease Family

Elena M. Ibryashkina, Giedrius Sasnauskas, Alexander S. Solonin, Marina V. Zakharova, Virginijus Siksnys

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 345 KB

english, 2009

38

Alternative arrangements of catalytic residues at the active sites of restriction enzymes

Gintautas Tamulaitis, Alexander S. Solonin, Virginijus Siksnys

Journal:

Year:

2002

Language:

english

File:

PDF, 299 KB

english, 2002

39

The Metal-independent Type IIs Restriction Enzyme BfiI is a Dimer that Binds Two DNA Sites but has Only One Catalytic Centre

Arunas Lagunavicius, Giedrius Sasnauskas, Stephen E Halford, Virginijus Siksnys

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 1.22 MB

english, 2003

40

Direct Visualization of the EcoRII−DNA Triple Synaptic Complex by Atomic Force Microscopy †

Shlyakhtenko, Luda S., Gilmore, Jamie, Portillo, Alex, Tamulaitis, Gintautas, Siksnys, Virginijus, Lyubchenko, Yuri L.

Journal:

Year:

2007

Language:

english

File:

PDF, 503 KB

english, 2007

41

In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus

Sinkunas, Tomas, Gasiunas, Giedrius, Waghmare, Sakharam P, Dickman, Mark J, Barrangou, Rodolphe, Horvath, Philippe, Siksnys, Virginijus

Journal:

The EMBO Journal

Year:

2013

Language:

english

File:

PDF, 1.25 MB

english, 2013

42

The link between restriction endonuclease fidelity and oligomeric state: A study with Bse634I

Mindaugas Zaremba, Giedrius Sasnauskas, Virginijus Siksnys

Journal:

Year:

2012

Language:

english

File:

PDF, 603 KB

english, 2012

43

crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus

Karvelis, Tautvydas, Gasiunas, Giedrius, Miksys, Algirdas, Barrangou, Rodolphe, Horvath, Philippe, Siksnys, Virginijus

Journal:

Year:

2013

Language:

english

File:

PDF, 2.30 MB

english, 2013

44

Strategy for Stabilizing Enzymes Part One: Increasing Stability of Enzymes via their Multi-Point Interaction with a Support

Mozhaev, V. V., Melik-nubarov, N. S., Sergeeva, M. V., Šikšnis, Virginius, Martinek, Karel

Journal:

Biocatalysis and Biotransformation

Year:

1990

Language:

english

File:

PDF, 562 KB

english, 1990

45

Towards Integrated Data Analytics: Time Series Forecasting in DBMS

Ulrike Fischer, Lars Dannecker, Laurynas Siksnys, Frank Rosenthal…

Journal:

Datenbank-Spektrum

Year:

2013

Language:

english

File:

PDF, 616 KB

english, 2013

46

RNA-dependent DNA endonuclease Cas9 of the CRISPR system: Holy Grail of genome editing?

Gasiunas, Giedrius, Siksnys, Virginijus

Journal:

Trends in Microbiology

Year:

2013

Language:

english

File:

PDF, 358 KB

english, 2013

47

Molecular mechanisms of CRISPR-mediated microbial immunity

Gasiunas, Giedrius, Sinkunas, Tomas, Siksnys, Virginijus

Journal:

Cellular and Molecular Life Sciences

Year:

2014

Language:

english

File:

PDF, 673 KB

english, 2014

48

Molecular scissors under light control

Zaremba, M., Siksnys, V.

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 547 KB

english, 2010

49

Revealing Restriction Enzyme Dynamics With Fast-scan Afm

Gilmore, Jamie L., Suzuki, Yuki, Tamulaitis, Gintautus, Lushnikov, Alexander Y., Siksnys, Virginijus, Takeyasu, Kunio, Lyubchenko, Yuri L.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 86 KB

english, 2009

50

CAATTG-specific restriction-modification munI genes from Mycoplasma: sequence similarities between R · MunI and R · EcoRI

Siksnys, Virginijus, Zareckaja, Natalja, Vaisvila, Romualdas, Timinskas, Albertas, Stakenas, Petras, Butkus, Viktoras, Janulaitis, Arvydas

Journal:

Year:

1994

Language:

english

File:

PDF, 1.09 MB

english, 1994